Results of a prospective study of positron emission tomography-directed management of residual nodal abnormalities in node-positive head and neck cancer after definitive radiotherapy with or without systemic therapy

Porceddu, Sandro V., Pryor, David I., Burmeister, Elizabeth, Burmeister, Bryan H., Poulsen, Michael G., Foote, Matthew C., Panizza, Benedict, Coman, Scott, McFarlane, David and Coman, William (2011). Results of a prospective study of positron emission tomography-directed management of residual nodal abnormalities in node-positive head and neck cancer after definitive radiotherapy with or without systemic therapy. In: 52nd Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO), San Diego, United States, (1675-1682). 31 October - 4 November 2010. doi:10.1002/hed.21655


Author Porceddu, Sandro V.
Pryor, David I.
Burmeister, Elizabeth
Burmeister, Bryan H.
Poulsen, Michael G.
Foote, Matthew C.
Panizza, Benedict
Coman, Scott
McFarlane, David
Coman, William
Title of paper Results of a prospective study of positron emission tomography-directed management of residual nodal abnormalities in node-positive head and neck cancer after definitive radiotherapy with or without systemic therapy
Conference name 52nd Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO)
Conference location San Diego, United States
Conference dates 31 October - 4 November 2010
Journal name Head and Neck   Check publisher's open access policy
Place of Publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Publication Year 2011
Year available 2011
Sub-type Fully published paper
DOI 10.1002/hed.21655
Open Access Status Not yet assessed
ISSN 1043-3074
1097-0347
Volume 33
Issue 12
Start page 1675
End page 1682
Total pages 8
Language eng
Abstract/Summary Background. The purpose of this study was to present our prospectively evaluated positron emission tomography (PET)-directed policy for managing the neck in node-positive head and neck squamous cell carcinoma (N+HNSCC) after definitive radiotherapy (RT) with or without concurrent systemic therapy.
Formatted Abstract/Summary
Background: The purpose of this study was to present our prospectively evaluated positron emission tomography (PET)-directed policy for managing the neck in node-positive head and neck squamous cell carcinoma (N+HNSCC) after definitive radiotherapy (RT) with or without concurrent systemic therapy.

Methods:
One hundred twelve consecutive patients who achieved a complete response at the primary site underwent a 12-week posttherapy nodal response assessment with PET and diagnostic CT. Patients with an equivocal PET underwent a repeat PET 4 to 6 weeks later. Patients with residual CT nodal abnormalities deemed PET-negative were uniformly observed regardless of residual nodal size.

Results: Median follow-up from commencement of RT was 28 months (range, 13–64 months). Residual CT nodal abnormalities were present in 50 patients (45%): 41 PET-negative and 9 PET-positive. All PET-negative residual CT nodal abnormalities were observed without subsequent isolated nodal failure.

Conclusion:
PET-directed management of the neck after definitive RT in node-positive HNSCC appropriately spares neck dissections in patients with PET-negative residual CT nodal abnormalities.
Keyword Head and neck
Squamous cell carcinoma
Pet
Radiotherapy
Chemotherapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collections: Official 2012 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 85 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 94 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 02 Jan 2012, 00:03:02 EST by System User on behalf of Scholarly Communication and Digitisation Service