The standard electrode potential (E-theta) predicts the prooxidant activity and the acute toxicity of metal ions

Kinraide, Thomas B., Poschenrieder, Charlotte and Kopittke, Peter M. (2011) The standard electrode potential (E-theta) predicts the prooxidant activity and the acute toxicity of metal ions. Journal of Inorganic Biochemistry, 105 11: 1438-1445. doi:10.1016/j.jinorgbio.2011.08.024


Author Kinraide, Thomas B.
Poschenrieder, Charlotte
Kopittke, Peter M.
Title The standard electrode potential (E-theta) predicts the prooxidant activity and the acute toxicity of metal ions
Formatted title
The standard electrode potential (Eθ) predicts the prooxidant activity and the acute toxicity of metal ions
Journal name Journal of Inorganic Biochemistry   Check publisher's open access policy
ISSN 0162-0134
1873-3344
Publication date 2011-11-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jinorgbio.2011.08.024
Open Access Status Not yet assessed
Volume 105
Issue 11
Start page 1438
End page 1445
Total pages 8
Editor Christopher Exley
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 1303 Biochemistry
1604 Inorganic Chemistry
Abstract The standard electrode potential (E-theta) has been known for many decades to predict the toxicity of metal ions. We have compiled acute toxicity data from fifteen studies and find that the toxicity of thirty metal ions correlates with E-theta at r(2) = 0.868 when toxicity is expressed as log concentration of comparably effective doses. We have discovered an even stronger relationship between the prooxidant activity (PA) of metal ions and E-theta (and electronegativity, chi). Data compiled from thirty-four studies demonstrate that the PA of twenty-five metal ions correlates with E-theta at r(2) = 0.983 (and chi at r(2) = 0.968). PA was commonly measured as metal-induced peroxidation of cell membranes or accumulation of reactive oxygen species. None of the redox metals (capable of Fenton-like reactions) in our studies (i.e., Mn, Fe, Co, Ni, and Cu) was prooxidative or toxic beyond what was expected from E-theta or chi. We propose that the formation of superoxide-metal ion complexes is greater at greater E-theta or chi values and that these complexes, whether free or enzyme-bound, function in PA without redox cycling of the complexed ion. Published by Elsevier Inc.
Formatted abstract
The standard electrode potential (Eθ) has been known for many decades to predict the toxicity of metal ions. We have compiled acute toxicity data from fifteen studies and find that the toxicity of thirty metal ions correlates with Eθ at r2 = 0.868 when toxicity is expressed as log concentration of comparably effective doses. We have discovered an even stronger relationship between the prooxidant activity (PA) of metal ions and Eθ (and electronegativity, χ). Data compiled from thirty-four studies demonstrate that the PA of twenty-five metal ions correlates with Eθ at r2 = 0.983 (and χ at r2 = 0.968). PA was commonly measured as metal-induced peroxidation of cell membranes or accumulation of reactive oxygen species. None of the redox metals (capable of Fenton-like reactions) in our studies (i.e., Mn, Fe, Co, Ni, and Cu) was prooxidative or toxic beyond what was expected from Eθ or χ. We propose that the formation of superoxide-metal ion complexes is greater at greater Eθ or χ values and that these complexes, whether free or enzyme-bound, function in PA without redox cycling of the complexed ion.
Keyword Electronegativity
Metal ion
Prooxidant
Standard electrode potential
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID BFU2010-14873
Institutional Status UQ
Additional Notes Keele Special Issue: Aluminum and Life - Living the in Aluminum Age

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Agriculture and Food Sciences
 
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