3,4 '-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: Synthesis using crossed-aldol chemistry and preliminary biological evaluations

Banwell, Martin G., Coster, Mark J., Hungerford, Natasha L., Garson, Mary J., Su, Stephen, Kotze, Andrew C. and Munro, Murray H. G. (2012) 3,4 '-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: Synthesis using crossed-aldol chemistry and preliminary biological evaluations. Organic and Biomolecular Chemistry, 10 1: 154-161. doi:10.1039/c1ob06418e


Author Banwell, Martin G.
Coster, Mark J.
Hungerford, Natasha L.
Garson, Mary J.
Su, Stephen
Kotze, Andrew C.
Munro, Murray H. G.
Title 3,4 '-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: Synthesis using crossed-aldol chemistry and preliminary biological evaluations
Journal name Organic and Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
1477-0539
Publication date 2012-01-07
Year available 2011
Sub-type Article (original research)
DOI 10.1039/c1ob06418e
Open Access Status Not Open Access
Volume 10
Issue 1
Start page 154
End page 161
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Formatted abstract
Compounds 2–5, incorporating various elements of the 3,4¢-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published on the web 27 Sep 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 23 Dec 2011, 18:35:12 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences