Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis

Chang, A. B., Byrnes, C. A. and Everard, M. L. (2011) Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis. Paediatric Respiratory Reviews, 12 2: 97-103. doi:10.1016/j.prrv.2010.10.008

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Author Chang, A. B.
Byrnes, C. A.
Everard, M. L.
Title Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis
Journal name Paediatric Respiratory Reviews   Check publisher's open access policy
ISSN 1526-0542
1526-0550
Publication date 2011-06-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.prrv.2010.10.008
Open Access Status Not yet assessed
Volume 12
Issue 2
Start page 97
End page 103
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Current diagnostic labelling of childhood bronchiectasis by radiology has substantial limitations. These include the requirement for two high resolution computerised tomography [HRCT] scans (with associated adversity of radiation) if criteria is adhered to, adoption of radiological criteria for children from adult data, relatively high occurrence of false negative, and to a smaller extent false positive, in conventional HRCT scans when compared to multi-detector CT scans, determination of irreversible airway dilatation, and absence of normative data on broncho-arterial ratio in children.
Formatted abstract
Current diagnostic labelling of childhood bronchiectasis by radiology has substantial limitations. These include the requirement for two high resolution computerised tomography [HRCT] scans (with associated adversity of radiation) if criteria is adhered to, adoption of radiological criteria for children from adult data, relatively high occurrence of false negative, and to a smaller extent false positive, in conventional HRCT scans when compared to multi-detector CT scans, determination of irreversible airway dilatation, and absence of normative data on broncho-arterial ratio in children.

A paradigm presenting a spectrum related to airway bacteria, with associated degradation and inflammation products causing airway damage if untreated, entails protracted bacterial bronchitis (at the mild end) to irreversible airway dilatation with cystic formation as determined by HRCT (at the severe end of the spectrum). Increasing evidence suggests that progression of airway damage can be limited by intensive treatment, even in those predestined to have bronchiectasis (eg immune deficiency). Treatment is aimed at achieving a cure in those at the milder end of the spectrum to limiting further deterioration in those with severe ‘irreversible’ radiological bronchiectasis.
Keyword Bronchiectasis
Suppurative lung-disease
Children
Prevention
Diagnosis
Chronic lung disease
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 545216
Institutional Status UQ
Additional Notes Mini-Symposium: Non-CF Bronchiectasis

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 21 Dec 2011, 23:58:03 EST by Jane Medhurst on behalf of Child Health Research Centre