ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012) ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 D1: D325-D330. doi:10.1093/nar/gkr886

Author Kaas, Quentin
Yu, Rilei
Jin, Ai-Hua
Dutertre, Sebastien
Craik, David J.
Title ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
Publication date 2012-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1093/nar/gkr886
Open Access Status DOI
Volume 40
Issue D1
Start page D325
End page D330
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 1311 Genetics
Abstract ConoServer ( is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails are carnivorous gastropods, which hunt their prey using a cocktail of toxins that potently subvert nervous system function. The ability of these toxins to specifically target receptors, channels and transporters of the nervous system has attracted considerable interest for their use in physiological research and as drug leads. Since the founding publication on ConoServer in 2008, the number of entries in the database has nearly doubled, the interface has been redesigned and new annotations have been added, including a more detailed description of cone snail species, biological activity measurements and information regarding the identification of each sequence. Automatically updated statistics on classification schemes, three-dimensional structures, conopeptide-bearing species and endoplasmic reticulum signal sequence conservation trends, provide a convenient overview of current knowledge on conopeptides. Transcriptomics and proteomics have began generating massive numbers of new conopeptide sequences, and two dedicated tools have been recently implemented in ConoServer to standardize the analysis of conopeptide precursor sequences and to help in the identification by mass spectrometry of toxins whose sequences were predicted at the nucleic acid level.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631457
Institutional Status UQ
Additional Notes First published online: November 3, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Created: Tue, 20 Dec 2011, 22:07:20 EST by Susan Allen on behalf of Institute for Molecular Bioscience