The burden of disease in non-cystic fibrosis bronchiectasis

Kapur, Nitin, Masters, I. Brent, Newcombe, Peter and Chang, Anne B. (2012) The burden of disease in non-cystic fibrosis bronchiectasis. Chest, 141 4: 1018-1024. doi:10.1378/chest.11-0679


Author Kapur, Nitin
Masters, I. Brent
Newcombe, Peter
Chang, Anne B.
Title The burden of disease in non-cystic fibrosis bronchiectasis
Journal name Chest   Check publisher's open access policy
ISSN 0012-3692
1931-3543
Publication date 2012-04-01
Year available 2011
Sub-type Article (original research)
DOI 10.1378/chest.11-0679
Open Access Status Not yet assessed
Volume 141
Issue 4
Start page 1018
End page 1024
Total pages 6
Place of publication Northbrook, IL, United States
Publisher American College of Chest Physicians
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
2706 Critical Care and Intensive Care Medicine
2705 Cardiology and Cardiovascular Medicine
Abstract Background: The burden of disease in children with non-cystic fibrosis (non-CF) bronchiectasis is unknown. Our study aimed to identify the determinants of quality of life (QOL) and parental mental health in this group of patients and their parents and to evaluate the effect of exacerbations on these parameters.
Formatted abstract
Background:
The burden of disease in children with non-cystic fibrosis (CF) bronchiectasis is unknown. Our study aimed to identify the determinants of quality of life (QOL) and parental mental health in this group of patients and their parents; and to evaluate the effect of exacerbations on these parameters.

Methods:

Parents of 69 children (median age 7 years) with non-CF bronchiectasis prospectively completed two questionnaires [parent-proxy cough-specific QOL (PC-QOL) and Depression, Anxiety and Stress scale (DASS)] at stable and exacerbation states. Data on clinical, investigational and lung function parameters were also collected.

Results
:
During stable-state, the median [Inter-quartile range (IQR)] PC-QOL was 6.5 (5.3-6.9) and DASS-21 was 6 (0-20). Young age of children correlated with worse QOL (rs=0.242, p=0.04) but radiological extent, lung function, underlying etiology, environmental tobacco smoke exposure and chronic upper-airway disease did not influence these scores. Exacerbations caused significant worsening in PC-QOL [median (IQR) 4.6 (3.8-5.4); p=<0.001] and DASS scores [22 (9-42); p<0.001; 38% with elevated anxiety 54% abnormal depression/stress scores during exacerbation]. Presence of viral infection, hypoxia and hospitalization did not influence exacerbation PC-QOL and DASS scores.

Conclusions:

There is a significant burden of disease, especially during exacerbation, on parents of children with bronchiectasis. Prevention, early detection and appropriate management of exacerbations are likely to reduce psychological morbidity in this group.
Keyword Critical Care Medicine
Respiratory System
General & Internal Medicine
Respiratory System
CRITICAL CARE MEDICINE
RESPIRATORY SYSTEM
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 545216
Institutional Status UQ
Additional Notes Published online 1 September 2011.

 
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Created: Mon, 19 Dec 2011, 23:24:57 EST by Jane Medhurst on behalf of Child Health Research Centre