Swallowing, nutrition and patient-rated functional outcomes at 6 months following two non-surgical treatments for T1-T3 oropharyngeal cancer

Cartmill, Bena, Cornwell, Petrea, Ward, Elizabeth, Davidson, Wendy and Porceddu, Sandro (2012) Swallowing, nutrition and patient-rated functional outcomes at 6 months following two non-surgical treatments for T1-T3 oropharyngeal cancer. Supportive Care in Cancer, 20 9: 2073-2081. doi:10.1007/s00520-011-1316-4

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Author Cartmill, Bena
Cornwell, Petrea
Ward, Elizabeth
Davidson, Wendy
Porceddu, Sandro
Title Swallowing, nutrition and patient-rated functional outcomes at 6 months following two non-surgical treatments for T1-T3 oropharyngeal cancer
Journal name Supportive Care in Cancer   Check publisher's open access policy
ISSN 0941-4355
1433-7339
Publication date 2012-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s00520-011-1316-4
Open Access Status File (Author Post-print)
Volume 20
Issue 9
Start page 2073
End page 2081
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Altered fractionation radiotherapy with concomitant boost (AFRT-CB) may be considered an alternative treatment for patients not appropriate for chemoradiation (CRT). As functional outcomes following AFRT-CB have been minimally reported, this exploratory paper describes the outcomes of patients managed with AFRT-CB or CRT at 6 months post-treatment.
Formatted abstract
Purpose:
Altered fractionation radiotherapy with concomitant boost (AFRT-CB) may be considered an alternative treatment for patients not appropriate for chemoradiation (CRT). As functional outcomes following AFRT-CB have been minimally reported, this exploratory paper describes the outcomes of patients managed with AFRT-CB or CRT at 6 months post-treatment.

Methods:
Using a cross-sectional analysis design, functional outcomes of 14 AFRT-CB and 17 CRT patients with T1-T3 oropharyngeal cancers were explored at 6 months post-treatment. Clinical and instrumental swallow assessments, weight and nutritional status, and the functional impact of treatment were examined.

Results:
Inferior outcomes were observed for the CRT patients on the RBHOMS (p = 0.03) which was reflected in diet and fluid restrictions with 18% of the CRT group requiring modified fluids and diets. Although a trend (p = 0.07) was noted for increased lingual deficits and aspiration risk for fluids in the CRT group, no other significant differences were observed. Both groups experienced an average of 10 kg weight loss and reported reduced general and swallowing-related function.

Conclusions:
These preliminary data suggest functional outcomes following AFRT-CB and CRT were largely comparable at 6 months post-treatment. Treatment intensification in any form may contribute to impaired function which requires multidimensional intervention. Larger cohort investigations with systematic methodology are needed to further examine these initial findings.
Keyword Altered fractionation radiotherapy
Chemoradiation
Nutrition
Oropharyngeal cancer
Swallowing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 15 November 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Created: Mon, 19 Dec 2011, 21:48:01 EST by Matthew Lamb on behalf of School of Medicine