The developmental vitamin D (DVD) model of schizophrenia

Eyles, Darryl, Burne, Thomas H.J., Alexander, Suzy, Cui, Xiaoying and McGrath, John J. (2011). The developmental vitamin D (DVD) model of schizophrenia. In Patricio O’Donnell and Wolfgang Walz (Ed.), Animal Models of Schizophrenia and Related Disorders (pp. 113-125) New York , NY, U.S.A.: Humana Press. doi:10.1007/978-1-61779-157-4_5

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Author Eyles, Darryl
Burne, Thomas H.J.
Alexander, Suzy
Cui, Xiaoying
McGrath, John J.
Title of chapter The developmental vitamin D (DVD) model of schizophrenia
Title of book Animal Models of Schizophrenia and Related Disorders
Language of Book Title eng
Place of Publication New York , NY, U.S.A.
Publisher Humana Press
Publication Year 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-1-61779-157-4_5
Open Access Status Not yet assessed
Year available 2011
Series Neuromethods
ISBN 9781617791567
9781617791574
ISSN 0893-2336
1940-6045
Editor Patricio O’Donnell
Wolfgang Walz
Volume number 59
Chapter number 5
Start page 113
End page 125
Total pages 13
Total chapters 12
Language eng
Abstract/Summary It is now widely acknowledged that exposure to adverse environmental factors in utero may not only affect how the brain develops but have long-lasting consequences for later brain function in the adult offspring. This idea has gained particular prominence amongst researchers interested in the etiology of neurodevelopmental disorders such as schizophrenia and autism. Approximately 10 years ago we proposed that developmental vitamin D (DVD) deficiency may explain several epidemiological features of this disease, most noticeably the winter/spring season of birth effect. In 2003 we published results from our first study indicating there were structural changes in how the brain develops in these offspring. Since then we have firmly established that DVD deficiency not only affects brain cell differentiation and gross anatomy but also produces alterations in behavior in these offspring as adults. In this chapter we describe how we came to construct the model we use today. Over the past 7 years the model has proved informative producing both structural brain changes (ventriculomegaly) and behavioral alterations (hyperlocomotion in response to NMDA antagonists) that are thought to be relevant to schizophrenia.
Formatted Abstract/Summary
It is now widely acknowledged that exposure to adverse environmental factors in utero may not only affect how the brain develops but have long-lasting consequences for later brain function in the adult offspring. This idea has gained particular prominence amongst researchers interested in the etiology of neurodevelopmental disorders such as schizophrenia and autism. Approximately 10 years ago we proposed that developmental vitamin D (DVD) deficiency may explain several epidemiological features of this disease, most noticeably the winter/spring season of birth effect. In 2003 we published results from our first study indicating there were structural changes in how the brain develops in these offspring. Since then we have firmly established that DVD deficiency not only affects brain cell differentiation and gross anatomy but also produces alterations in behavior in these offspring as adults. In this chapter we describe how we came to construct the model we use today. Over the past 7 years the model has proved informative producing both structural brain changes (ventriculomegaly) and behavioral alterations (hyperlocomotion in response to NMDA antagonists) that are thought to be relevant to schizophrenia.
Keyword Vitamin D
Brain
Animal model
Development
Schizophrenia
Behavior
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Figures

Document type: Book Chapter
Collections: Queensland Brain Institute Publications
Official 2012 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 13 Dec 2011, 20:51:51 EST by Debra McMurtrie on behalf of Queensland Brain Institute