Reorganizing metals: The use of chelating compounds as potential therapies for metal-related neurodegenerative disease

Badrick, Alison C. and Jones, Christopher E. (2011) Reorganizing metals: The use of chelating compounds as potential therapies for metal-related neurodegenerative disease. Current Topics in Medicinal Chemistry, 11 5: 543-552. doi:10.2174/156802611794785181

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Author Badrick, Alison C.
Jones, Christopher E.
Title Reorganizing metals: The use of chelating compounds as potential therapies for metal-related neurodegenerative disease
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
1873-4294
Publication date 2011-03-01
Sub-type Article (original research)
DOI 10.2174/156802611794785181
Volume 11
Issue 5
Start page 543
End page 552
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegenerative disorders. In the brain, as elsewhere in the body, metal ion excess or deficiency can potentially inhibit protein function, interfere with correct protein folding or, in the case of iron or copper, promote oxidative stress. The involvement of metal ions in neurodegenerative disorders has made them an emerging target for therapeutic interventions. One approach has been to chelate and sequester the ions and thus limit their potential to interfere with protein folding or render them unable to undergo redox processes. Newer approaches suggest that redistributing metal ions has therapeutic benefits, and recent studies indicate that alleviating cellular copper deficiency may be a plausible way to limit neurodegeneration. In this review we discuss the role of metals in amyloidogenic, neurodegenerative disorders and highlight some mechanisms and compounds used in various therapeutic approaches.
Keyword Alzheimer's
Chelator
Copper
Iron
Neurodegeneration
Parkinson's
Prion
Redox
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Wed, 07 Dec 2011, 19:48:57 EST by Debra McMurtrie on behalf of Queensland Brain Institute