Leukemia Inhibitory Factor Rescues Motoneurons From Axotomy-Induced Cell-Death

Cheema, SS, Richards, LJ, Murphy, M and Bartlett, PF (1994) Leukemia Inhibitory Factor Rescues Motoneurons From Axotomy-Induced Cell-Death. Neuroreport, 5 8: 989-992. doi:10.1097/00001756-199404000-00034

Author Cheema, SS
Richards, LJ
Murphy, M
Bartlett, PF
Title Leukemia Inhibitory Factor Rescues Motoneurons From Axotomy-Induced Cell-Death
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
Publication date 1994-04-01
Year available 1994
Sub-type Article (original research)
DOI 10.1097/00001756-199404000-00034
Open Access Status Not yet assessed
Volume 5
Issue 8
Start page 989
End page 992
Total pages 4
Place of publication LONDON
Language eng
Abstract THE death of spinal motoneurones after axotomy provides a useful model for studying novel factors which prevent motoneurone loss in vivo. Peripheral nerves of newborn rats were unilaterally transected and treated with either a vehicle solution or leukaemia inhibitory factor (LIF). Compared with the vehicle controls, treatment with a gelfoam containing LIF significantly reduced motoneurone loss: from 38% to 22% after 3 days and from 55% to 38% after 7 days. The loss of motoneurones was further reduced by placing the LIF-containing gelfoam inside a silicone chamber: from 39% to 15% after 7 days, which represented a 62% rescue. Thus, LIF is a potential therapeutic agent for preventing the loss of injured or diseased motoneurones.
Keyword Leukemia Inhibitory Factor
Motoneuron Rescue
Spinal Cord
Motoneuron Disease
Motor Neurons
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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