Regulation of the Early Development of the Nervous-System by Growth-Factors

Bartlett, PF, Kilpatrick, TJ, Richards, LJ, Talman, PS and Murphy, M (1994) Regulation of the Early Development of the Nervous-System by Growth-Factors. Pharmacology & Therapeutics, 64 3: 371-393. doi:10.1016/0163-7258(94)00044-1


Author Bartlett, PF
Kilpatrick, TJ
Richards, LJ
Talman, PS
Murphy, M
Title Regulation of the Early Development of the Nervous-System by Growth-Factors
Journal name Pharmacology & Therapeutics   Check publisher's open access policy
ISSN 0163-7258
Publication date 1994-01-01
Year available 1994
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/0163-7258(94)00044-1
Open Access Status Not yet assessed
Volume 64
Issue 3
Start page 371
End page 393
Total pages 23
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Abstract Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.
Keyword Neural Precursors
Clonal Analysis
Fibroblast Growth Factors
Neural Crest
Multipotentiality
Lineage Commitment
Neural Crest Cells
Leukemia-Inhibitory Factor
Ciliary Neurotrophic Factor
Glial Progenitor-Cell
Rat Optic-Nerve
Type-2 Astrocyte Development
Factor Stimulates Survival
Tyrosine Kinase Receptor
Clonally Related Cells
Mediated Gene-Transfer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: ResearcherID Downloads - Archived
 
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