Retinal axon guidance by region-specific cues in diencephalon

Tuttle, R, Braisted, JE, Richards, LJ and O'Leary, DDM (1998) Retinal axon guidance by region-specific cues in diencephalon. Development, 125 5: 791-801.

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Author Tuttle, R
Braisted, JE
Richards, LJ
O'Leary, DDM
Title Retinal axon guidance by region-specific cues in diencephalon
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 1998-03-01
Year available 1998
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 125
Issue 5
Start page 791
End page 801
Total pages 11
Place of publication CAMBRIDGE
Language eng
Abstract Retinal axons show region-specific patterning along the dorsal-ventral axis of diencephalon: retinal axons grow in a compact bundle over hypothalamus, dramatically splay out over thalamus, and circumvent epithalamus as they continue toward the dorsal midbrain. In vitro, retinal axons are repulsed by substrate-bound and soluble activities in hypothalamus and epithalamus, but invade thalamus. The repulsion is mimicked by a soluble floor plate activity. Tenascin and neurocan, extracellular matrix molecules that inhibit retinal axon growth in vitro, are enriched in hypothalamus and epithalamus. Within thalamus, a stimulatory activity is specifically upregulated in target nuclei at the time that retinal axons invade them. These findings suggest that region-specific, axon repulsive and stimulatory activities control retinal axon patterning in the embryonic diencephalon.
Keyword chemorepulsion
floor plate
lateral geniculate nucleus
visual system development
Chondroitin Sulfate Proteoglycan
Receptor Tyrosine Kinases
Developmentally-Regulated Expression
Lateral Geniculate-Nucleus
Chick Visual-System
Female Albino-Rat
Optic Chiasm
Neurite Outgrowth
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 EY07025
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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