Retinotectal maps: molecules, models and misplaced data

Goodhill, GJ and Richards, LJ (1999) Retinotectal maps: molecules, models and misplaced data. Trends in Neurosciences, 22 12: 529-534. doi:10.1016/S0166-2236(99)01469-1

Author Goodhill, GJ
Richards, LJ
Title Retinotectal maps: molecules, models and misplaced data
Journal name Trends in Neurosciences   Check publisher's open access policy
ISSN 0166-2236
Publication date 1999-12-01
Year available 1999
Sub-type Article (original research)
DOI 10.1016/S0166-2236(99)01469-1
Open Access Status Not yet assessed
Volume 22
Issue 12
Start page 529
End page 534
Total pages 6
Place of publication LONDON
Language eng
Abstract The mechanisms underlying the formation of topographic maps in the retinotectal system have long been debated. Recently, members of the Eph and ephrin receptor-ligand family have been found to provide a molecular substrate for one type of mechanism,that of chemospecific gradient matching, as proposed by Sperry. However, experiments over several-decades have demonstrated that there is more to map formation than gradient matching. This article briefly reviews the old and new findings, argues that these two types of data must be properly integrated in order to understand map formation fully and suggests some experimental and theoretical ways to begin this process.
Keyword Ganglion-Cell Axons
Patterned Neural Connections
Receptor Tyrosine Kinases
Half Retinal Projection
Optic Tectum
Positional Markers
Nerve Connections
Topographic Order
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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Citation counts: TR Web of Science Citation Count  Cited 78 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 77 times in Scopus Article | Citations
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