Chronic respiratory symptoms, von Willebrand factor and longitudinal decline in FEV1

Chambers, DC, Boldy, DAR and Ayres, JG (1999) Chronic respiratory symptoms, von Willebrand factor and longitudinal decline in FEV1. Respiratory Medicine, 93 10: 726-733. doi:10.1016/S0954-6111(99)90040-9


Author Chambers, DC
Boldy, DAR
Ayres, JG
Title Chronic respiratory symptoms, von Willebrand factor and longitudinal decline in FEV1
Journal name Respiratory Medicine   Check publisher's open access policy
ISSN 0954-6111
Publication date 1999-10-01
Year available 1999
Sub-type Article (original research)
DOI 10.1016/S0954-6111(99)90040-9
Open Access Status DOI
Volume 93
Issue 10
Start page 726
End page 733
Total pages 8
Place of publication LONDON
Publisher W B SAUNDERS CO LTD
Language eng
Abstract Although some risk factors for accelerated decline in forced expiratory volume in 1 s (FEV1) such as cigarette smoking, are well defined, it is not possible to identify those individuals with the most rapid rates of decline. Von Willebrand factor (vWF) is a product of both the pulmonary and systemic endothelium, and serum levels are raised during episodes of acute bronchitis. We hypothesized that raised serum levels of vWF may indicate sub-clinical pulmonary injury and so may predict subsequent accelerated decline in FEV1. The aims of this study were 1, to define the prevalence of chronic respiratory symptoms and obstructive airway disease in an inner-city British population and 2. to determine whether elevated levels of von Willebrand factor (vWF) identify those individuals at risk for more rapid decline in FEV1 over time.
Keyword Vonwillebrand-Factor Antigen
Forced Expiratory Volume
Pulmonary-Function
Smoking Cessation
Distress-Syndrome
Adults
Prevalence
Age
Hypertension
Bronchitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 30 Nov 2011, 22:00:40 EST by System User