Relationship between changes in body weight and cognitive function in middle-aged and older women

Lo, Ada H. Y., Pachana, Nancy A., Byrne, Gerard J., Sachdev, Perminder S. and Woodman, Richard J. (2012) Relationship between changes in body weight and cognitive function in middle-aged and older women. International Journal of Geriatric Psychiatry, 27 8: 863-872. doi:10.1002/gps.2797

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Author Lo, Ada H. Y.
Pachana, Nancy A.
Byrne, Gerard J.
Sachdev, Perminder S.
Woodman, Richard J.
Title Relationship between changes in body weight and cognitive function in middle-aged and older women
Journal name International Journal of Geriatric Psychiatry   Check publisher's open access policy
ISSN 0885-6230
1099-1166
Publication date 2012-08-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/gps.2797
Open Access Status Not Open Access
Volume 27
Issue 8
Start page 863
End page 872
Total pages 10
Place of publication Bognor Regis, West Sussex, U.K.
Publisher John Wiley & Sons
Language eng
Abstract The bone-specific physical activity questionnaire (BPAQ) accounts for activities that affect bone but has not been used in studies with older adults. Relationships exist between the BPAQ-derived physical activity and bone density in healthy middle-aged and older men but not men with prostate cancer. Disease-related treatments detrimental to bone should be considered when administering the BPAQ.
Formatted abstract
Background: Although several longitudinal studies indicate that weight loss precedes dementia in men and women, the relationship between weight changes and cognitive performance is unclear. This study investigated the relationship between changes in adiposity and cognitive function in community-dwelling women.

Methods: Data were derived from the Longitudinal Assessment of Women Study, a population-based study of 511 urban women initially aged 40–79 years. We analyzed data from 334 women who had complete information on demographics, cardiovascular risk factors, medical status, weight, height, and waist-to-hip ratio and cognitive scores at baseline and after a mean of 7.45 years of follow-up. Cognition was assessed at baseline and follow-up using the Mini Mental State Examination; the Auditory Delayed Index, Visual Delayed Index, and Working Memory Index from the Wechsler Memory Scale, Third Edition; and the Processing Speed Index from the Wechsler Adult Intelligence Scale, Third Edition. Associations were adjusted for age, education, baseline cognitive performance, cardiovascular risk factors, menopausal status, and apolipoprotein E-4 status.

Results: In multivariate analysis, both weight gain and loss were associated with poor Visual Delayed Index performance at follow-up compared with stable weight (β = −4.02 ± 1.57, p = 0.011; β = −6.50 ± 2.39, p = 0.007, respectively). No significant associations were found between body mass index, waist circumference, or waist-to-hip ratio and any cognitive domains at follow-up. Changes in cognitive performance were not associated with changes in adiposity measures.

Conclusion: Weight loss and weight gain were associated with poor cognitive performance in middle-aged and older women compared with women with stable weight.
Keyword Adiposity
Aging
Cognitive functioning
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 456182
Institutional Status UQ
Additional Notes Article first published online: 11 October 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 28 Nov 2011, 21:23:45 EST by Sheila Cleary on behalf of School of Psychology