Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications

Dargaville, Bronwin L., Vaquette, Cedryck, Peng, Hui, Rasoul, Firas, Chua, Yu Qian, Cooper-White, Justin J., Campbell, Julie H. and Whittaker, Andrew K. (2011) Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications. Biomacromolecules, 12 11: 3856-3869. doi:10.1021/bm201291e


Author Dargaville, Bronwin L.
Vaquette, Cedryck
Peng, Hui
Rasoul, Firas
Chua, Yu Qian
Cooper-White, Justin J.
Campbell, Julie H.
Whittaker, Andrew K.
Title Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications
Formatted title
Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2011-11-14
Sub-type Article (original research)
DOI 10.1021/bm201291e
Volume 12
Issue 11
Start page 3856
End page 3869
Total pages 14
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2012
Language eng
Formatted abstract
A series of copolymers of trimethylene carbonate (TMC) and l-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility properties were evaluated. High TMC polymers showed mechanical properties comparable to human arteries (Young’s moduli of 1.2–1.8 MPa and high elasticity with repeated cycling at 10% strain). Over 84 days degradation in PBS, the modulus and material strength decreased gradually. The polymers were nontoxic and showed good cell adhesion and proliferation over 7 days using human mesenchymal stem cells. When implanted into the rat peritoneal cavity, the polymers elicited formation of tissue capsules composed of myofibroblasts, resembling immature vascular smooth muscle cells. Thus, these polymers showed properties which were tunable and favorable for vascular tissue engineering, specifically, the growth of artificial blood vessels in vivo.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 21 Nov 2011, 19:41:21 EST by Professor Andrew Whittaker on behalf of School of Chemistry & Molecular Biosciences