Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women

Krebs, J. D., Browning, L. M., McLean, N. K., Rothwell, J. L., Mishra, G. D., Moore, C. S. and Jebb, S. A. (2006) Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. International Journal of Obesity, 30 10: 1535-1544. doi:10.1038/sj.ijo.0803309


Author Krebs, J. D.
Browning, L. M.
McLean, N. K.
Rothwell, J. L.
Mishra, G. D.
Moore, C. S.
Jebb, S. A.
Title Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women
Journal name International Journal of Obesity   Check publisher's open access policy
ISSN 0307-0565
1476-5497
Publication date 2006-10-01
Year available 2006
Sub-type Article (original research)
DOI 10.1038/sj.ijo.0803309
Open Access Status DOI
Volume 30
Issue 10
Start page 1535
End page 1544
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Background: Obesity, inflammation, insulin resistance and cardiovascular disease (CVD) risk are inter-related. Both weight-loss and long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) are independently known to reduce metabolic risk, but the combined effects are unclear.
Formatted abstract
Background: Obesity, inflammation, insulin resistance and cardiovascular disease (CVD) risk are inter-related. Both weight-loss and long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) are independently known to reduce metabolic risk, but the combined effects are unclear.
Objective: This study examines whether addition of LC n-3 PUFA to a low fat/high carbohydrate weight-loss programme results in greater improvements in inflammation, insulin sensitivity and CVD risk, than weight-loss alone.
Design: One hundred and sixteen overweight insulin-resistant women entered a 24-week randomised intervention study. Thirty-nine women were randomised to a weight-loss programme, with LC n-3 PUFA (WLFO), 38 to a weight-loss programme with placebo oil (WLPO), and 39 to receive placebo oil, with no weight-loss programme (control).
Results: Ninety-three women completed the study (35 WLFO, 32 WLPO and 26 control), with significant weight-loss in WLFO (10.8plusminus1.0%) and WLPO (12.4plusminus1.0%) compared to the control group (P<0.0001). The WLFO, but not WLPO or control group, showed significant increases in adipose tissue LC n-3 PUFA (0.34plusminus0.20 vs 0.17plusminus0.10 and 0.16plusminus0.10 %DHA, P<0.0001). Weight-loss showed significant improvements in insulin sensitivity (P<0.001), lipid profile (triglycerides P<0.05) and inflammation (sialic acid P<0.05). Timemidastgroup effects showed significant decreases in triglycerides (P<0.05) and increases in adiponectin (P<0.01) with LC n-3 PUFA, in the WLFO vs WLPO groups.
Conclusions: Weight-loss improved risk factors associated with CVD, with some additional benefits of LC n-3 PUFA on triglycerides and adiponectin. Given the current low dietary intake of LC n-3 PUFA, greater attention should be given to increase these fatty acids in the treatment of obesity.
Keyword Adiponectin
Weight-loss
Insulin sensitivity
Fish oil
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MC_U105960384
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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