Mathematical models of skin permeability: An overview

Mitragotri, Samir, Anissimov, Yuri G., Bunge, Annette L., Frasch, H. Frederick, Guy, Richard H., Hadgraft, Jonathan, Kasting, Gerald B., Lane, Majella E. and Roberts, Michael S. (2011) Mathematical models of skin permeability: An overview. International Journal of Pharmaceutics, 418 1: 115-129. doi:10.1016/j.ijpharm.2011.02.023

Author Mitragotri, Samir
Anissimov, Yuri G.
Bunge, Annette L.
Frasch, H. Frederick
Guy, Richard H.
Hadgraft, Jonathan
Kasting, Gerald B.
Lane, Majella E.
Roberts, Michael S.
Title Mathematical models of skin permeability: An overview
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 2011-10-01
Sub-type Article (original research)
DOI 10.1016/j.ijpharm.2011.02.023
Open Access Status Not yet assessed
Volume 418
Issue 1
Start page 115
End page 129
Total pages 15
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 3003 Pharmaceutical Science
Abstract Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure–permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects.
Keyword Transdermal
Stratum corneum
Exposure assessment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
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