Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis

Forouzanfar, Mohammad H., Foreman, Kyle J., Delossantos, Allyne M., Lozano, Rafael, Lopez, Alan D., Murray, Christopher J. L. and Naghavi, Mohsen (2011) Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis. Lancet, 378 9801: 1461-1484. doi:10.1016/S0140-6736(11)61351-2

Author Forouzanfar, Mohammad H.
Foreman, Kyle J.
Delossantos, Allyne M.
Lozano, Rafael
Lopez, Alan D.
Murray, Christopher J. L.
Naghavi, Mohsen
Title Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 2011-10-01
Sub-type Article (original research)
DOI 10.1016/S0140-6736(11)61351-2
Open Access Status Not yet assessed
Volume 378
Issue 9801
Start page 1461
End page 1484
Total pages 24
Place of publication London, England, U.K.
Publisher The Lancet Publishing Group
Language eng
Subject 2700 Medicine
Abstract Breast and cervical cancer are important causes of mortality in women aged ≥15 years. We undertook annual age-specific assessments of breast and cervical cancer in 187 countries. We systematically collected cancer registry data on mortality and incidence, vital registration, and verbal autopsy data for the period 1980-2010. We modelled the mortality-to-incidence (MI) ratio using a hierarchical model. Vital registration and verbal autopsy were supplemented with incidence multiplied by the MI ratio to yield a comprehensive database of mortality rates. We used Gaussian process regression to develop estimates of mortality with uncertainty by age, sex, country, and year. We used out-of-sample predictive validity to select the final model. Estimates of incidence with uncertainty were also generated with mortality and MI ratios. Global breast cancer incidence increased from 641 000 (95 uncertainty intervals 610 000-750 000) cases in 1980 to 1 643 000 (1 421 000-1 782 000) cases in 2010, an annual rate of increase of 3·1. Global cervical cancer incidence increased from 378 000 (256 000-489 000) cases per year in 1980 to 454 000 (318 000-620 000) cases per year in 2010 - a 0·6 annual rate of increase. Breast cancer killed 425 000 (359 000-453 000) women in 2010, of whom 68 000 (62 000-74 000) were aged 15-49 years in developing countries. Cervical cancer death rates have been decreasing but the disease still killed 200 000 (139 000-276 000) women in 2010, of whom 46 000 (33 000-64 000) were aged 15-49 years in developing countries. We recorded pronounced variation in the trend in breast cancer mortality across regions and countries. More policy attention is needed to strengthen established health-system responses to reduce breast and cervical cancer, especially in developing countries. Susan G Komen for the Cure and the Bill & Melinda Gates Foundation.
Keyword Human-Papillomavirus
Recent Trends
Time Trends
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
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