Bronchoscopic assessment of wheezy infants: Should this be a clinical routine?

Martinez, Manuel Soto and Sly, Peter D. (2009) Bronchoscopic assessment of wheezy infants: Should this be a clinical routine?. Salud(i)Ciencia, 16 8: 845-847.

Author Martinez, Manuel Soto
Sly, Peter D.
Title Bronchoscopic assessment of wheezy infants: Should this be a clinical routine?
Journal name Salud(i)Ciencia   Check publisher's open access policy
ISSN 1667-8982
Publication date 2009-07-01
Sub-type Article (original research)
Volume 16
Issue 8
Start page 845
End page 847
Total pages 3
Place of publication Buenos Aires, Argentina
Publisher Sociedad Iberoamericana de Informacion Cientifica (S I I C)
Language spa
Abstract Determining which preschool-aged children with recurrent or persistent wheezing are likely to develop persistent asthma is difficult. The situation is compounded by the relatively poor response to anti-asthma treatment reported from most clinical trials in this age group. Recent publications have demonstrated that bronchoscopic assessment, including bronchoalveolar lavage (BAL) and endobronchial biopsy, can be performed safely in young children. We argue that such assessment could provide valuable information on the pathogenesis of asthma in early life and potentially allow the identification of which individual wheezy children are likely to progress to persistent asthma. Based on data in the literature, we contend that children who are at high risk of developing persistent asthma based on risk factors identified from longitudinal epidemiological studies (e. g. a family history of atopy and asthma; early allergic sensitization; clinical food allergy; eczema associated with atopy; and lower respiratory illnesses associated with wheezing in the first years of life) and who continue to wheeze beyond their third birthday would benefit from bronchoscopic evaluation. The presence of eosinophilic inflammation in BAL and/or biopsy and reticular basement membrane thickening may indicate a high likelihood of persistent asthma. However, the predictions need to be tested by collecting the appropriate data.
Keyword Persistent asthma
Airway remodeling
Bronchoalveolar lavage
Bronchial biopsy
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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