Cyclic nucleotide-dependent switching of mammalian axon guidance depends on gradient steepness

Thompson, Andrew W., Pujic, Zac, Richards, Linda J. and Goodhill, Geoffrey J. (2011) Cyclic nucleotide-dependent switching of mammalian axon guidance depends on gradient steepness. Molecular and Cellular Neuroscience, 47 1: 45-52. doi:10.1016/j.mcn.2011.02.012

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Author Thompson, Andrew W.
Pujic, Zac
Richards, Linda J.
Goodhill, Geoffrey J.
Title Cyclic nucleotide-dependent switching of mammalian axon guidance depends on gradient steepness
Journal name Molecular and Cellular Neuroscience   Check publisher's open access policy
ISSN 1044-7431
Publication date 2011-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.mcn.2011.02.012
Open Access Status File (Author Post-print)
Volume 47
Issue 1
Start page 45
End page 52
Total pages 8
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Subject 1312 Molecular Biology
2804 Cellular and Molecular Neuroscience
1307 Cell Biology
Abstract Correct wiring of the nervous system during development requires axons to respond appropriately to gradients of attractive and repulsive guidance cues. However, the steepness and concentration of these gradients vary in vivo, for instance, with distance from the target. Understanding how these changing conditions affect the navigation strategies used by developing axons is important for understanding how they are guided over long distances. Previous work has shown that cyclic nucleotide levels determine whether axons are attracted or repelled by steep gradients of the same guidance cue, but it is unknown whether this is also true for shallow gradients. We therefore investigated the guidance responses of rat superior cervical ganglion (SCG) axons in both steep and shallow gradients of nerve growth factor (NGF). In steep gradients we found that cyclic nucleotide-dependent switching occurred, consistent with previous reports. Surprisingly however, we found that in shallow NGF gradients, cyclic nucleotide-dependent switching did not occur. These results suggest that there may be substantial differences in the way axons respond to gradient-based guidance cues depending on where they are within the gradient.
Keyword Axon guidance
Cyclic AMP (cAMP)
Growth cone
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP0666126
Institutional Status UQ

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Created: Thu, 10 Nov 2011, 22:51:05 EST by Debra McMurtrie on behalf of Queensland Brain Institute