Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings

Middledorp, Christel M., Birley, Andrew J., Cath, Danielle C., Gillespie, Nathan A., Willemsen, Gonneke, Statham, Dixie J., de Geus, Eco J. C., Andrews, J. Gavin, van Dyck, Richard, Beem, A. Leo, Sullivan, Patrick F., Martin, Nicholas G. and Boomsma, Dorret I. (2005) Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. Twin Research and Human Genetics, 8 6: 609-615. doi:10.1375/183242705774860123

Author Middledorp, Christel M.
Birley, Andrew J.
Cath, Danielle C.
Gillespie, Nathan A.
Willemsen, Gonneke
Statham, Dixie J.
de Geus, Eco J. C.
Andrews, J. Gavin
van Dyck, Richard
Beem, A. Leo
Sullivan, Patrick F.
Martin, Nicholas G.
Boomsma, Dorret I.
Title Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2005-12-01
Sub-type Article (original research)
DOI 10.1375/183242705774860123
Open Access Status Not Open Access
Volume 8
Issue 6
Start page 609
End page 615
Total pages 7
Place of publication Bowen Hills, Qld., Australia
Publisher Australian Academic Press
Language eng
Formatted abstract
The aim of this study was to investigate familial influences and their dependence on sex for panic disorder and/or agoraphobia, social phobia, generalized anxiety disorder and major depression. Data from Australian (N = 2287) and Dutch (N = 1185) twins and siblings who were selected for a linkage study and participated in clinical interviews to obtain lifetime Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) diagnoses were used. In a liability model, tetrachoric correlations were estimated in sibling pairs and sex differences between sibling correlations were tested. For each diagnosis, the sibling correlations could be constrained to be equal across the Australian and Dutch samples. With the exception of panic disorder and/or agoraphobia, all sibling correlations were the same for brother, sister and opposite-sex sibling pairs and were around .20. For panic disorder and/or agoraphobia, the correlation was .23 in brother and sister pairs, but absent in opposite-sex sibling pairs. From these results it can be concluded that upper heritability estimates, based on twice the correlations in the sibling pairs, vary between 36% (major depression) and 50% (social phobia). Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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