Investigation of hormone receptor genes in migraine

Colson, Natalie J., Lea, Rod A., Quinlan, Sharon, MacMillan, John and Griffiths, Lyn R. (2005) Investigation of hormone receptor genes in migraine. Neurogenetics, 6 1: 17-23. doi:10.1007/s10048-004-0205-0

Author Colson, Natalie J.
Lea, Rod A.
Quinlan, Sharon
MacMillan, John
Griffiths, Lyn R.
Title Investigation of hormone receptor genes in migraine
Journal name Neurogenetics   Check publisher's open access policy
ISSN 1364-6745
Publication date 2005-02-01
Sub-type Article (original research)
DOI 10.1007/s10048-004-0205-0
Open Access Status Not Open Access
Volume 6
Issue 1
Start page 17
End page 23
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation considered that genes involved in hormonal pathways may play a role in migraine susceptibility. We therefore investigated the androgen receptor (AR) CAG repeat, and the progesterone receptor (PR) PROGINS insert by cross-sectional association analysis. The results showed no association with the AR CAG repeat in our study group of 275 migraineurs and 275 unrelated controls. Results of the PR PROGINS analysis showed a significant difference in the same cohort, and in an independent follow-up study population of 300 migraineurs and 300 unrelated controls. Analysis of the genotypic risk groups of both populations together indicated that individuals who carried the PROGINS insert were 1.8 times more likely to suffer migraine. Interaction analysis of the PROGINS variant with our previously reported associated ESR1 594A variant showed that individuals who possessed at least one copy of both risk alleles were 3.2 times more likely to suffer migraine. Hence, variants of these steroid hormone receptor genes appear to act synergistically to increase the risk of migraine by a factor of three.
Keyword Androgen receptor gene
Progesterone receptor gene
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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