Follicular lymphoma: Time for a re-think?

Gandhi, Maher K. and Marcus, Robert E. (2005) Follicular lymphoma: Time for a re-think?. Blood Reviews, 19 3: 165-178. doi:10.1016/j.blre.2004.09.001

Author Gandhi, Maher K.
Marcus, Robert E.
Title Follicular lymphoma: Time for a re-think?
Journal name Blood Reviews   Check publisher's open access policy
ISSN 0268-960X
Publication date 2005-05-01
Year available 2004
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.blre.2004.09.001
Open Access Status Not Open Access
Volume 19
Issue 3
Start page 165
End page 178
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract Follicular lymphoma (FL) is a malignancy of follicle centre B cells that have at least a partially follicular pattern, and is the commonest type of indolent Non-Hodgkin’s lymphoma. Except in the subset of patients with localized disease, FL should still be regarded as an incurable malignancy with a relentless relapsing/remitting course. However, the provocative new data covered by this review (including anti-CD20 antibody therapy, BCL-2, radioimmunotherapy, new chemotherapeutic agents and anti-idiotype vaccination), provides much cause for excitement and guarded optimism. Rituximab represents a novel treatment approach for a variety of disease settings, with a proven excellent efficacy and toxicity profile. Long-term data is required to establish whether its use translates into survival benefit. As the clinical activity of rituximab and other new therapeutic approaches becomes established, it will be important to determine how best to integrate these results into the standard care of patients with follicular lymphoma.
Keyword Follicular lymphoma
Non-Hodgkin’s lymphoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 1 October 2004

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
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