Evidence of conserved neuroendocrine interactions in the thymus: Intrathymic expression of neuropeptides in mammalian and non-mammalian vertebrates

Silva, Alberto B. and Palmer, Donald B. (2011) Evidence of conserved neuroendocrine interactions in the thymus: Intrathymic expression of neuropeptides in mammalian and non-mammalian vertebrates. Neuroimmunomodulation, 18 5: 264-270. doi:10.1159/000329493


Author Silva, Alberto B.
Palmer, Donald B.
Title Evidence of conserved neuroendocrine interactions in the thymus: Intrathymic expression of neuropeptides in mammalian and non-mammalian vertebrates
Journal name Neuroimmunomodulation   Check publisher's open access policy
ISSN 1021-7401
1423-0216
Publication date 2011-09-01
Sub-type Article (original research)
DOI 10.1159/000329493
Open Access Status Not Open Access
Volume 18
Issue 5
Start page 264
End page 270
Total pages 7
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Abstract The function of lymphoid organs and immune cells is often modulated by hormones, steroids and neuropeptides produced by the neuroendocrine and immune systems. The thymus intrinsically produces these factors and a comparative analysis of the expression of neuropeptides in the thymus of different species would highlight the evolutionary importance of neuroendocrine interaction in T cell development. In this review, we highlight the evidence which describes the intrathymic expression and function of various neuropeptides and their receptors, in particular somatostatin, substance P, vasointestinal polypeptide, calcitonin gene-related peptide and neuropeptide Y, in mammals (human, rodent) and non-mammals (avian, amphibian and teleost), and conclude that neuropeptides play a conserved role in vertebrate thymocyte development.
Keyword Neuroendocrine
Neuropeptide
Thymic epithelial cells
Thymocytes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 08 Nov 2011, 01:17:50 EST by Alberto Boucas Da Silva on behalf of Institute for Molecular Bioscience