Regional distribution of nitrergic neurons in the inner retina of the chicken

Wilson, Martin, Nacsa, Nick, Hart, Nathan S., Weller, Cynthia and Vaney, David I. (2011) Regional distribution of nitrergic neurons in the inner retina of the chicken. Visual Neuroscience, 28 3: 205-220. doi:10.1017/S0952523811000083

Author Wilson, Martin
Nacsa, Nick
Hart, Nathan S.
Weller, Cynthia
Vaney, David I.
Title Regional distribution of nitrergic neurons in the inner retina of the chicken
Journal name Visual Neuroscience   Check publisher's open access policy
ISSN 0952-5238
Publication date 2011-05-01
Sub-type Article (original research)
DOI 10.1017/S0952523811000083
Open Access Status Not yet assessed
Volume 28
Issue 3
Start page 205
End page 220
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Formatted abstract
Using both NADPH diaphorase and anti-nNOS antibodies, we have identified—from retinal flatmounts—neuronal types in the inner retina of the chicken that are likely to be nitrergic. The two methods gave similar results and yielded a total of 15 types of neurons, comprising 9 amacrine cells, 5 ganglion cells, and 1 centrifugal midbrain neuron. Six of these 15 cell types are ubiquitously distributed, comprising 3 amacrine cells, 2 displaced ganglion cells, and a presumed orthotopic ganglion cell. The remaining nine cell types are regionally restricted within the retina. As previously reported, efferent fibers of midbrain neurons and their postsynaptic partners, the unusual axon-bearing target amacrine cells, are entirely confined to the ventral retina. Also confined to the ventral retina, though with somewhat different distributions, are the “bullwhip” amacrine cells thought to be involved in eye growth, an orthotopic ganglion cell, and two types of large axon-bearing amacrine cells whose dendrites and axons lie in stratum 1 of the inner plexiform layer (IPL). Intracellular fills of these two cell types showed that only a minority of otherwise morphologically indistinguishable neurons are nitrergic. Two amacrine cells that branch throughout the IPL are confined to an equatorial band, and one small-field orthotopic ganglion cell that branches in the proximal IPL is entirely dorsal. These findings suggest that the retina uses different processing on different regions of the visual image, though the benefit of this is presently obscure.
Keyword NADPH diaphorase
Amacrine cell
Ganglion cell
Nitric oxide
Nitric-oxide synthase
Ganglion-cell layer
Factor-like immunoreactivity
Glucagon-expressing neurons
Polyaxonal amacrine cells
NADPH-diaphorase activity
Domain factor Brn-3b
Rabbit retina
Turtle retina.
Horizontal cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 03 Nov 2011, 21:25:34 EST by Debra McMurtrie on behalf of Queensland Brain Institute