Custom-made composite scaffolds for segmental defect repair in long bones

Reichert, J.C. and Wullschleger, M.E. (2010) Custom-made composite scaffolds for segmental defect repair in long bones. International Orthopaedics, 35 8: 1229-1236. doi:10.1007/s00264-010-1146-x

Author Reichert, J.C.
Wullschleger, M.E.
Title Custom-made composite scaffolds for segmental defect repair in long bones
Journal name International Orthopaedics   Check publisher's open access policy
ISSN 0341-2695
Publication date 2010-12-07
Sub-type Fully published paper
DOI 10.1007/s00264-010-1146-x
Open Access Status Not Open Access
Volume 35
Issue 8
Start page 1229
End page 1236
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Current approaches for segmental bone defect reconstruction are restricted to autografts and allografts which possess osteoconductive, osteoinductive and osteogenic properties, but face significant disadvantages. The objective of this study was to compare the regenerative potential of scaffolds with different material composition but similar mechanical properties to autologous bone graft from the iliac crest in an ovine segmental defect model. After 12 weeks, in vivo specimens were analysed by X-ray imaging, torsion testing, micro-computed tomography and histology to assess amount, strength and structure of the newly formed bone. The highest amounts of bone neoformation with highest torsional moment values were observed in the autograft group and the lowest in the medical grade polycaprolactone and tricalcium phosphate composite group. The study results suggest that scaffolds based on aliphatic polyesters and ceramics, which are considered biologically inactive materials, induce only limited new bone formation but could be an equivalent alternative to autologous bone when combined with a biologically active stimulus such as bone morphogenetic proteins.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Fully published paper
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Created: Wed, 02 Nov 2011, 04:23:19 EST by Martin Wullschleger on behalf of Surgery - Royal Brisbane and Women's Hospital