Passage of 4-nonylphenol across the human placenta

Balakrishnan, B., Thorstensen, E., Ponnampalam, A. and Mitchell, M. D. (2011) Passage of 4-nonylphenol across the human placenta. Placenta, 32 10: 788-792. doi:10.1016/j.placenta.2011.07.014

Author Balakrishnan, B.
Thorstensen, E.
Ponnampalam, A.
Mitchell, M. D.
Title Passage of 4-nonylphenol across the human placenta
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2011-10-01
Sub-type Article (original research)
DOI 10.1016/j.placenta.2011.07.014
Open Access Status Not Open Access
Volume 32
Issue 10
Start page 788
End page 792
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
4-nonylphenol (4-NP) is an estrogenic endocrine active chemical that is present in detergents and is known to contaminate food and drinking water. The aim of the present study was to evaluate whether 4-NP crosses the human placenta and if so, to what extent. Human placentae obtained from healthy term singleton pregnancies were utilized in a dual ex-vivo re-circulating model of placental perfusion. Six placentae were perfused for 180 min following addition of 4-NP (30 ng/mL) to the maternal perfusate. Antipyrine and FITC dextran were used as positive and negative controls respectively to validate the integrity of the circuits. 4-NP was measured by High Performance Liquid Chromatography coupled with Fluorescence Detection (HPLC-FD). After 180 min of perfusion the transfer percentages for antipyrine and 4-NP were 25.6 ± 1.4% (mean ± s.e.m, n = 6) and 22.75 ± 3.76% respectively and the transfer index for 4-NP was 0.8. We conclude that the intact form of 4-NP at environmentally relevant concentrations can transfer across the human placenta albeit at a slow rate.
Keyword 4-nonylphenol
Placental transfer
Placental perfusion
Endocrine disruptors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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