Doppler tissue echocardiographic features of cardiac amyloidosis

Palka, P, Lange, A, Donnelly, JE, Scalia, G, Burstow, DJ and Nihoyannopoulos, P (2002) Doppler tissue echocardiographic features of cardiac amyloidosis. Journal of the American Society of Echocardiography, 15 11: 1353-1360. doi:10.1067/mje.2002.125285

Author Palka, P
Lange, A
Donnelly, JE
Scalia, G
Burstow, DJ
Nihoyannopoulos, P
Title Doppler tissue echocardiographic features of cardiac amyloidosis
Journal name Journal of the American Society of Echocardiography   Check publisher's open access policy
ISSN 0894-7317
Publication date 2002-11-01
Year available 2002
Sub-type Article (original research)
DOI 10.1067/mje.2002.125285
Open Access Status Not yet assessed
Volume 15
Issue 11
Start page 1353
End page 1360
Total pages 8
Place of publication ST LOUIS
Publisher MOSBY, INC
Language eng
Abstract The purpose of the study was to assess whether quantification of myocardial involvement by Doppler tissue echocardiography (DTE) enhances the accuracy of echocardiographic characterization of cardiac amyloidosis (CA). A group of 36 patients with CA (mean age 58 +/- 13 years; 22 male) and 40 age-matched control patients were studied. Patients with CA were divided into CA-1 subgroup with nonrestrictive (n = 22) and CA-2 with restrictive left ventricular (LV) filling pattern (n = 14). Peak lateral and medial mitral annulus velocities by pulsed wave DTE were measured in systole, early diastole, and late diastole. Using color M-mode DTE of the IV posterior wall, mean myocardial velocities (MMV) and myocardial velocity gradient (MVG) were measured during ventricular ejection, early and late isovolumic relaxation (IVR), rapid ventricular filling, and atrial contraction. in both CA-1 and CA-2 groups, mitral annulus velocities, MMV, and all MVG were lower than those measured in control patients, with the exception of peak late diastolic annulus velocities at lateral side and MMV in atrial contraction. MVGs in both early IVR and rapid ventricular filling were lower in the CA-1 as compared with the CA-2 group. Late IVR-MVG was negative in control patients and positive in patients with CA indicating a faster movement of the subendocardium. rather than the subepicardium during late IVR in patients with CA (0.88 +/- 0.50 s(-1) vs -0.40 +/- 1.59 s(-1); P < .001). The following parameters: peak early diastolic annulus velocities at lateral side less than or equal to -12 cm/s, peak early diastolic annulus velocities at medial side :5 - 10 cm/s, early IVR-MMV less than or equal to 2.5 cm/s, early IVR-MVG less than or equal to -0.7 s(-1), and late YVR-WG greater than or equal to 0.5 s(-1) differentiated patients with CA from control patients with an overall accuracy of 0.82, 0.83, 0.81, 0.87, and 0.81, respectively. In patients with CA, reduction in early IVR-MMV was independent of patients' age and LV mass. DTE indices proved helpful in differentiating patients with CA from control patients including those patients with CA who had borderline conventional echocardiographic features and nonrestrictive LV filling pattern.
Keyword Myocardial Velocity-Gradient
Ventricular Diastolic Function
Mitral Annulus Velocity
Pulmonary Venous Flow
Hypertrophic Cardiomyopathy
Restrictive Cardiomyopathy
Constrictive Pericarditis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
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