Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin

Karagas, Margaret R., Nelson, Heather H., Sehr, Peter, Waterboer, Tim, Stukel, Therese A., Andrew, Angeline, Green, Adele C., Bavinck, Jan Nico Bouwes, Perry, Ann, Spencer, Steven, Rees, Judy R., Mott, Leila A. and Pawlita, Michael (2006) Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. Journal of the National Cancer Institiute, 98 6: 389-395. doi:10.1093/jnci/djj092

Author Karagas, Margaret R.
Nelson, Heather H.
Sehr, Peter
Waterboer, Tim
Stukel, Therese A.
Andrew, Angeline
Green, Adele C.
Bavinck, Jan Nico Bouwes
Perry, Ann
Spencer, Steven
Rees, Judy R.
Mott, Leila A.
Pawlita, Michael
Title Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin
Journal name Journal of the National Cancer Institiute   Check publisher's open access policy
ISSN 0027-8874
Publication date 2006-03-15
Sub-type Article (original research)
DOI 10.1093/jnci/djj092
Open Access Status Not Open Access
Volume 98
Issue 6
Start page 389
End page 395
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background: Although infection with human papillomaviruses (HPVs) is a major risk factor for several epithelial cancers, an etiologic relationship between HPV and keratinocyte cancers, such as squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), remains unclear. Methods: In a population-based case–control study of 252 SCC case patients, 525 BCC case patients, and 461 control subjects, we used multiplex serology to detect antibodies in plasma samples against 16 HPV types from phylogenetic genera alpha, beta, and mu. Multiplex serology is a new method that is based on fluorescent bead technology and allows simultaneous detection of antibodies against up to 100 different in situ affinity-purified recombinant HPV proteins. Data on sun sensitivity, outdoor exposure, and other risk factors for keratinocyte cancers were collected through personal interviews. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via unconditional logistic regression models. Results: Overall, we detected HPV antibodies more frequently in SCC patients than in control subjects (OR = 1.6, 95% CI = 1.2 to 2.3), but we found no difference in HPV seropositivity between BCC case patients and control subjects (OR = 0.8, 95% CI = 0.6 to 1.1). Among HPV types, seropositivity to HPV types in genus beta (OR = 1.5, 95% CI = 1.0 to 2.1), particularly HPV 5 (OR = 1.8, 95% CI = 1.0 to 3.1), was associated with SCC risk. Individuals with tumors on chronically sun exposed sites were more likely to be seropositive for beta HPV types than individuals with SCC at other anatomic sites. The highest SCC risk was associated with positivity for multiple HPV types and, among individuals seropositive for HPV beta, a tendency to sunburn; however, the associations had limited statistical precision. Conclusions: Our findings support a role for HPV types from the genus beta in the pathogenesis of SCC.
Keyword basal cell carcinoma
cutaneous squamous cell carcinoma
keratinocyte cancer
menopausal hormone therapy
oral contraceptive
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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School of Public Health Publications
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Created: Wed, 26 Oct 2011, 01:46:28 EST by Geraldine Fitzgerald on behalf of School of Public Health