Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Waterboer, Tim, Neale, Rachel, Michael, Kristina M., Sehr, Peter, de Koning, Maurits N. C., Weissenborn, Sonke J., Sampogna, Francesca, Abeni, Damiano, Green, Adele C., Bavinck, Jan Nico Bouwes, Pawlita, Michael and EPI-HPV-UV-CA Group (2009) Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia. Journal of General Virology, 90 8: 1986-1998. doi:10.1099/vir.0.010637-0


Author Waterboer, Tim
Neale, Rachel
Michael, Kristina M.
Sehr, Peter
de Koning, Maurits N. C.
Weissenborn, Sonke J.
Sampogna, Francesca
Abeni, Damiano
Green, Adele C.
Bavinck, Jan Nico Bouwes
Pawlita, Michael
EPI-HPV-UV-CA Group
Title Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2009-08-01
Sub-type Article (original research)
DOI 10.1099/vir.0.010637-0
Open Access Status Not Open Access
Volume 90
Issue 8
Start page 1986
End page 1998
Total pages 13
Place of publication Reading, Berks., United Kingdom
Publisher Society for General Microbiology
Language eng
Abstract Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50–57 % for β-HPV types, 40–48 % for γ-HPV types), and the most frequent β-HPV and γ-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both β-HPV [odds ratio (OR) 2.81, 95 % confidence interval (CI) 1.64–4.82] and γ-HPV (OR 2.42, 95 % CI 1.40–4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and β-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 26 Oct 2011, 01:41:31 EST by Geraldine Fitzgerald on behalf of School of Public Health