Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals

Chen, Nanhua, Auliff, Alyson, Rieckmann, Karl, Gatton, Michelle and Cheng, Qin (2007) Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals. Journal of Infectious Diseases, 195 7: 934-941. doi:10.1086/512242


Author Chen, Nanhua
Auliff, Alyson
Rieckmann, Karl
Gatton, Michelle
Cheng, Qin
Title Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals
Formatted title
Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2007-04-01
Sub-type Article (original research)
DOI 10.1086/512242
Volume 195
Issue 7
Start page 934
End page 941
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
Plasmodium vivax infections are characterized by varying numbers of relapses occurring at different intervals as a result of activation of liver-stage hypnozoites. Parasite or host factors that determine the number and timing of relapses are unclear. In the present article, we report the analysis of relapse patterns and molecular characterization of parasites collected from Australian soldiers experiencing relapses of vivax malaria after exposure in East Timor. Although high molecular diversity was observed, a single allelic type was identified in association with 99% of relapses. Importantly, in 71% of patients experiencing >1 relapse, the allelic types were clonal and different in the 2 different relapses. These results, combined with those from a computer simulation model, suggest that a single hypnozoite clone was activated, causing a relapse, and that multiple relapses most likely arose from coordinated activation of hypnozoites originating from different parasite strains. These findings suggest remarkable regulation of relapse intervals in vivax malaria.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Public Health Publications
 
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Created: Tue, 25 Oct 2011, 23:08:52 EST by Geraldine Fitzgerald on behalf of School of Public Health