Impaired Fetal Blood-Gas Status in Polyhydramnios and its Relation to Raised Amniotic Pressure

Fisk, NM, Vaughan, J and Talbert, D (1994) Impaired Fetal Blood-Gas Status in Polyhydramnios and its Relation to Raised Amniotic Pressure. Fetal Diagnosis and Therapy, 9 1: 7-13. doi:10.1159/000263900


Author Fisk, NM
Vaughan, J
Talbert, D
Title Impaired Fetal Blood-Gas Status in Polyhydramnios and its Relation to Raised Amniotic Pressure
Journal name Fetal Diagnosis and Therapy   Check publisher's open access policy
ISSN 1015-3837
Publication date 1994-01-01
Year available 1994
Sub-type Article (original research)
DOI 10.1159/000263900
Open Access Status Not yet assessed
Volume 9
Issue 1
Start page 7
End page 13
Total pages 7
Place of publication BASEL
Publisher KARGER
Language eng
Abstract A substantial proportion of perinatal losses in polyhydramnios occur as unexplained normally formed stillbirths. In order to investigate the relationship between fetal condition and raised amniotic pressure (AP), fetal blood gas and acid-base status were determined together with AP in 22 pregnancies with polyhydramnios. At fetal blood sampling, 8 (36%) had a venous pH value and 16 (73%) a pO(2) value below the reference range. Both fetal pH and pO(2) were significantly negatively correlated with the degree of elevation in AP (y = 7.43 -0.036x, r = 0.56, p = 0.006, where y = pH and x = AP z score, and y = -1.6 - 0.48x, r = 0.54, p = O.O1, where y = pO(2) z score, respectively). Although some of these fetuses were hydropic, had congenital anomalies, or were from multiple pregnancies, univariate and multiple logistic regression analyses indicated that the above associations could not be accounted for by these potentially confounding variables. This work suggests that abnormal fetal blood gas status in human pregnancies with polyhydramnios is associated with elevated AP.
Keyword Polyhydramnios
Amniotic Pressure
Uteroplacental Perfusion
Fetal Blood Gas Status
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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