Uterine artery blood flow response to correction of amniotic fluid volume

Bower, Sarah J., Flack, Nicola J., Sepulveda, Waldo, Talbert, David G. and Fisk, Nicholas M. (1995) Uterine artery blood flow response to correction of amniotic fluid volume. American Journal of Obstetrics and Gynecology, 173 2: 502-507. doi:10.1016/0002-9378(95)90273-2

Author Bower, Sarah J.
Flack, Nicola J.
Sepulveda, Waldo
Talbert, David G.
Fisk, Nicholas M.
Title Uterine artery blood flow response to correction of amniotic fluid volume
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 1995-08-01
Sub-type Article (original research)
DOI 10.1016/0002-9378(95)90273-2
Open Access Status Not Open Access
Volume 173
Issue 2
Start page 502
End page 507
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Our purpose was to investigate whether acute alterations of amniotic fluid volume affect uteroplacental perfusion.


Three groups of patients of comparable gestational age were studied in a fetal medicine referral unit: (1) eight pregnancies with severe polyhydramnios because of twin-twin transfusion syndrome undergoing therapeutic amnioreduction, (2) seven with severe oligohydramnios undergoing diagnostic amnioinfusion, and (3) six control women having invasive procedures of similar duration without manipulation of amniotic fluid volume. Color Peppier imaging was used to measure uterine artery impedance index values and quantitative blood flow before and within 15 minutes of the end of the procedure.


Quantitative flow measurements increased after amnioreduction (74% median increase of volume flow, range 22% to 329%, p < 0.01) and decreased after amnioinfusion (33% median decrease of volume flow, range 17% to 51%, p < 0,05). Impedance index values increased after amnioinfusion (25% median increase in pulsatility index, range 4% to 71%, p < 0.05) and did not alter with amnioreduction. There were no significant changes in the control group.

Acute changes in amniotic fluid volume alter uteroplacental perfusion. In twin-twin transfusion syndrome amelioration in uterine flow may improve fetal condition and explain in part the success of serial amnioreduction therapy.
Keyword Amnioreduction
Uterine blood flow
Transfusion syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Citation counts: TR Web of Science Citation Count  Cited 60 times in Thomson Reuters Web of Science Article | Citations
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