Endothelin concentrations in monochorionic twins with severe twin-twin transfusion syndrome

Bajoria, R, Sullivan, M and Fisk, NM (1999) Endothelin concentrations in monochorionic twins with severe twin-twin transfusion syndrome. Human Reproduction, 14 6: 1614-1618. doi:10.1093/humrep/14.6.1614


Author Bajoria, R
Sullivan, M
Fisk, NM
Title Endothelin concentrations in monochorionic twins with severe twin-twin transfusion syndrome
Journal name Human Reproduction   Check publisher's open access policy
ISSN 0268-1161
Publication date 1999-06-01
Year available 1999
Sub-type Article (original research)
DOI 10.1093/humrep/14.6.1614
Open Access Status DOI
Volume 14
Issue 6
Start page 1614
End page 1618
Total pages 5
Place of publication OXFORD
Publisher OXFORD UNIV PRESS
Language eng
Abstract The objective of this study was to determine endothelin (ET-1) concentrations in monochorionic twin fetuses with and without twin-twin transfusion syndrome (TTTS). Fourteen monochorionic twin pregnancies complicated by TTTS and six without TTTS were studied. Matched maternal and fetal blood samples were obtained both iii utero and at birth. Amniotic fluid samples were also collected from twin pairs. ET-1 concentrations were measured by radio-immunoassay. ET-1 concentrations in recipient fetuses were higher than in the donors both in utero (P < 0.001) and at birth (P < 0.01). Fetal concentrations of ET-1 in donors were similar to non-TTTS twins. Plasma ET-1 concentrations were significantly higher (P < 0.01) in recipient fetuses with severe hydrops than those with mild/no hydrops. Maternal concentrations of ET-1 were comparable in the two groups. Endothelin concentrations in recipient twins were 2 1/2 times higher than in their co-twins and this was related to the severity of hydrops.
Keyword endothelin-1
fetal cardiac dysfunction
twin-twin transfusion syndrome
Intrauterine Growth-Retardation
Chronic Heart-Failure
Therapeutic Amniocentesis
Plasma Endothelin
Fetal
Rat
Polyhydramnios
Pregnancies
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Volume
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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