Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats

Tare, Marianne, Emmett, Sarah J., Coleman, Harold A., Skordilis, Con, Eyles, Darryl W., Morley, Ruth and Parkington, Helena C. (2011) Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. Journal of Physiology, 589 19: 4777-4786. doi:10.1113/jphysiol.2011.214726


Author Tare, Marianne
Emmett, Sarah J.
Coleman, Harold A.
Skordilis, Con
Eyles, Darryl W.
Morley, Ruth
Parkington, Helena C.
Title Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats
Journal name Journal of Physiology   Check publisher's open access policy
ISSN 0022-3751
1469-7793
Publication date 2011-10-01
Sub-type Article (original research)
DOI 10.1113/jphysiol.2011.214726
Open Access Status Not yet assessed
Volume 589
Issue 19
Start page 4777
End page 4786
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Increasing evidence links vitamin D deficiency and cardiovascular dysfunction in human adults. There is a worldwide increase in the prevalence of vitamin D deficiency in women of reproductive age, particularly dark-skinned and/or veiled women and their infants. We used a rat model to determine the functional impact of vitamin D deficiency during intra uterine and early life on resistance artery reactivity and blood pressure in the offspring as young adults. Rat dams were maintained on vitamin D deficient or replete chow before and during pregnancy and lactation. The offspring were maintained on the same chow until studied at 7-8 weeks of age. Conscious blood pressure was measured. Endothelial and smooth muscle function were tested in mesenteric arteries on a pressure myograph. Vitamin D deficient male and female offspring had a 10-fold lower serum 25-hydroxyvitamin D (P < 0.0001) and markedly elevated blood pressures (11-20 mmHg, P < 0.001) and heart rates (21-40 beats min-1, P < 0.02) than control fed offspring. Serum calcium was unchanged. Mesenteric artery myogenic tone was doubled in vitamin D deficiency. Endothelium-derived nitric oxide-evoked dilation was halved in arteries from vitamin D deficient males and dioestrous females. Dilation attributed to endothelium-derived hyperpolarizing factor was all but abolished in vitamin D deficient oestrous females. Nitroprusside-evoked dilation was unaltered in arteries from males, but was markedly reduced in vessels of vitamin D deplete females. In conclusion, early life vitamin D deficiency is associated with endothelial vasodilator dysfunction, and this is likely to contribute to the accompanying elevation in blood pressure and an increased cardiovascular disease risk.
Keyword D Deficiency
Blood-Pressure
Cardiovascular-Disease
Nitric-Oxide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
 
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