Bayesian estimation of extent of recovery for aspects of verbal memory in women undergoing adjuvant chemotherapy treatment for breast cancer

Rolfe, Margaret I., Mengersen, Kerrie L., Vearncombe, Katharine J., Andrew, Brooke and Beadle, Geoffrey F. (2011) Bayesian estimation of extent of recovery for aspects of verbal memory in women undergoing adjuvant chemotherapy treatment for breast cancer. Journal of the Royal Statistical Society Series C-Applied Statistics, 60 5: 655-674. doi:10.1111/j.1467-9876.2011.00766.x


Author Rolfe, Margaret I.
Mengersen, Kerrie L.
Vearncombe, Katharine J.
Andrew, Brooke
Beadle, Geoffrey F.
Title Bayesian estimation of extent of recovery for aspects of verbal memory in women undergoing adjuvant chemotherapy treatment for breast cancer
Journal name Journal of the Royal Statistical Society Series C-Applied Statistics   Check publisher's open access policy
ISSN 0035-9254
1467-9876
Publication date 2011-11-01
Sub-type Article (original research)
DOI 10.1111/j.1467-9876.2011.00766.x
Volume 60
Issue 5
Start page 655
End page 674
Total pages 20
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Decline in cognitive function can be experienced by up to 50% of women while undergoing adjuvant chemotherapy with a subset of patients experiencing long-term effects. Bayesian latent basis longitudinal random-effects and latent class growth models were used to assess the degree of verbal memory recovery for learning, immediate retention and delayed recall in women undergoing chemotherapy for early stage breast cancer and who were assessed before, and at 1, 6 and 18 months post chemotherapy. The latent basis model, with the initial time point fixed to 1 and the second to 0, enabled the estimation of the degree of recovery at times 3 and 4. In the single-class model, three prior distributions for the random effects were used, resulting in minimal differences in parameter estimation. These models resulted in a near complete recovery for learning, and 57-60% for immediate retention and delayed recall at 18 months post chemotherapy. A range of two- to five-class Bayesian mixture models were fitted, with classes differing for baseline and degree of recovery. In the three-class model, the 'Low' class indicated 29.0%, 11.0% and 9.6% recovery at 18 months post treatment for the three outcome measures respectively, indicating an extended time of reduced verbal memory function.
Keyword Adjuvant chemotherapy
Bayesian estimation
Breast cancer
Latent basis
Latent class growth
Longitudinal study
Verbal memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
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