Effect of Sodium Valproate On Naloxone-Stimulated Acth and Cortisol Release in Humans

Torpy, DJ, Grice, JE, Hockings, GI, Crosbie, GV, Walters, MM and Jackson, RV (1995) Effect of Sodium Valproate On Naloxone-Stimulated Acth and Cortisol Release in Humans. Clinical and Experimental Pharmacology and Physiology, 22 6-7: 441-443. doi:10.1111/j.1440-1681.1995.tb02037.x


Author Torpy, DJ
Grice, JE
Hockings, GI
Crosbie, GV
Walters, MM
Jackson, RV
Title Effect of Sodium Valproate On Naloxone-Stimulated Acth and Cortisol Release in Humans
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 1995-06-01
Year available 1995
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1995.tb02037.x
Open Access Status
Volume 22
Issue 6-7
Start page 441
End page 443
Total pages 3
Place of publication CARLTON
Publisher BLACKWELL SCIENCE PUBL AUSTR
Language eng
Abstract 1. Gamma-aminobutyric acid (GABA) and endogenous opioids each inhibit hypothalamic CRH secretion. In humans, the opioid antagonist, naloxone, stimulates the release of CRH, and so of ACTH and cortisol, while alprazolam, an indirect GABA(A) agonist, blocks naloxone-induced ACTH and cortisol secretion. Sodium valproate (SV) inhibits ACTH release in response to CRH, metyrapone and substance P. We hypothesized that, if this action is GABA(A)-mediated, SV should also inhibit naloxone-stimulated ACTH release.
Keyword Adrenocorticotropic Hormone
Corticotropin-Releasing Hormone
Human
Hydrocortisone
Hypothalamohypophyseal System
Naloxone
Sodium Valproate
Substance-P
Alprazolam
Axis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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