Fine tuning of the threshold of T cell selection by the Nck adapters

Roy, Edwige, Togbe, Dieudonnée, Holdorf, Amy, Trubetskoy, Dmitry, Nabti, Sabrina, Küblbeck, Günter, Schmitt, Sabine, Kopp-Schneider, Annette, Leithäuser, Frank, Möller, Peter, Bladt, Friedhelm, Hämmerling, Günter J., Arnold, Bernd, Pawson, Tony and Tafuri, Anna (2010) Fine tuning of the threshold of T cell selection by the Nck adapters. Journal of Immunology, 185 12: 7518-7526. doi:10.4049/jimmunol.1000008


Author Roy, Edwige
Togbe, Dieudonnée
Holdorf, Amy
Trubetskoy, Dmitry
Nabti, Sabrina
Küblbeck, Günter
Schmitt, Sabine
Kopp-Schneider, Annette
Leithäuser, Frank
Möller, Peter
Bladt, Friedhelm
Hämmerling, Günter J.
Arnold, Bernd
Pawson, Tony
Tafuri, Anna
Title Fine tuning of the threshold of T cell selection by the Nck adapters
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1550-6606
Publication date 2010-12-15
Sub-type Article (original research)
DOI 10.4049/jimmunol.1000008
Volume 185
Issue 12
Start page 7518
End page 7526
Total pages 9
Place of publication Bethesda, MD, United States
Publisher American Association of Immunologists
Language eng
Formatted abstract
Thymic selection shapes the T cell repertoire to ensure maximal antigenic coverage against pathogens while preventing autoimmunity. Recognition of self-peptides in the context of peptide-MHC complexes by the TCR is central to this process, which remains partially understood at the molecular level. In this study we provide genetic evidence that the Nck adapter proteins are essential for thymic selection. In vivo Nck deletion resulted in a reduction of the thymic cellularity, defective positive selection of low-avidity T cells, and impaired deletion of thymocytes engaged by low-potency stimuli. Nck-deficient thymocytes were characterized by reduced ERK activation, particularly pronounced in mature single positive thymocytes. Taken together, our findings identify a crucial role for the Nck adapters in enhancing TCR signal strength, thereby fine-tuning the threshold of thymocyte selection and shaping the preimmune T cell repertoire.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 22 Oct 2011, 03:50:10 EST by Edwige Roy on behalf of UQ Centre for Clinical Research