Clinical investigation of respiratory system admittance in preschool children

Simpson, Shannon J., Straszek, Sune P., Sly, Peter D., Stick, Stephen M. and Hall, Graham L. (2012) Clinical investigation of respiratory system admittance in preschool children. Pediatric Pulmonology, 47 1: 53-58. doi:10.1002/ppul.21515

Author Simpson, Shannon J.
Straszek, Sune P.
Sly, Peter D.
Stick, Stephen M.
Hall, Graham L.
Title Clinical investigation of respiratory system admittance in preschool children
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
Publication date 2012-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/ppul.21515
Open Access Status
Volume 47
Issue 1
Start page 53
End page 58
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
The upper airway shunt attenuates measurements of respiratory system impedance (Zrs), with greater impact in young children. Changes in respiratory system admittance, Ars (or Zrs-1), are theoretically independent of the shunt. This study compared the ability of Ars, to standard oscillatory outcomes, to determine respiratory disease and differentiate responses to inhaled bronchial challenges in the clinical setting.

The forced oscillation technique (FOT) was used to establish reference equations for Ars in healthy preschool children, compare the change in Ars to standard oscillatory outcomes during bronchial challenge with inhaled adenosine-5'-monosphate (AMP) and to inhaled bronchodilator in healthy children and those with respiratory disease.


Children with respiratory disease had lower baseline Ars than healthy children (P<0.05). However, there was no improved ability for Ars to differentiate between bronchodilator responses in healthy and disease populations. In contrast, the response to inhaled AMP occurred at a lower concentration, [25 (3.12-400) mgml-1; median (10th-90th centile)], as measured by Ars when compared to respiratory system resistance [225 (6.25-400) mgml-1; P=0.016].

This study supports the use of Ars during inhaled challenges, but not in response to bronchodilation. Pediatr Pulmonol.
Keyword Forced oscillation technique
Respiratory mechanics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 9 AUG 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Sat, 22 Oct 2011, 01:18:56 EST by Roxanne Jemison on behalf of Child Health Research Centre