Febrile respiratory illnesses in infancy &atopy are risk factors for persistent asthma and wheeze

Kusel, M. M. H., Kebadze, T., Johnston, S. L., Holt, P. G. and Sly, P. D. (2012) Febrile respiratory illnesses in infancy &atopy are risk factors for persistent asthma and wheeze. European Respiratory Journal, 39 4: 876-882. doi:10.1183/09031936.00193310

Author Kusel, M. M. H.
Kebadze, T.
Johnston, S. L.
Holt, P. G.
Sly, P. D.
Title Febrile respiratory illnesses in infancy &atopy are risk factors for persistent asthma and wheeze
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2012-04-01
Year available 2011
Sub-type Article (original research)
DOI 10.1183/09031936.00193310
Open Access Status DOI
Volume 39
Issue 4
Start page 876
End page 882
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Abstract Severe viral respiratory illnesses and atopy are risk factors for childhood wheezing and asthma. To explore associations between severe respiratory infections and atopy in early childhood with wheeze and asthma persisting into later childhood. 147 children at high atopic risk were followed from birth to 10years. Data on all respiratory infections occurring in infancy were collected prospectively and viral etiology ascertained. Atopy was measured by skin prick tests at 6months, 2 and 5years. History of wheeze and doctor-diagnosed eczema and asthma was collected regularly until 10years of age. At 10years 60% of the cohort was atopic, 25.9% had current eczema, 18.4% current asthma and 20.4% persistent wheeze. 35.8% experienced ≥one lower respiratory infection (LRI) associated with fever and/or wheeze in year1. Children who had wheezy, or in particular, febrile LRI in infancy and were atopic by 2years, were significantly more likely to have persistent wheeze (RR3.51; 95%CI 1.83-6.70; p<0.001) and current asthma (RR4.92; 95%CI 2.59-9.36; p<0.001) at 10years. Severe viral respiratory infections in infancy and early atopy are risk factors for persistent wheeze and asthma. The strongest marker of the asthmatogenic potential of early life infections was concurrent fever. The occurrence of fever during respiratory illnesses is an important marker of risk for wheeze and asthma later in childhood, suggesting it should be measured in prospective studies of asthma aetiology.
Keyword Asthma
Febrile infections
Persistent wheeze
Severe respiratory infections
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID P00/2
Institutional Status UQ
Additional Notes Published online before print September 15, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 47 times in Scopus Article | Citations
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Created: Sat, 22 Oct 2011, 01:16:37 EST by Roxanne Jemison on behalf of Child Health Research Centre