Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies

Shi, Feng, Liu, Bing, Zhou, Yuan, Yu, Chunshui and Jiang, Tianzi (2009) Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies. Hippocampus, 19 11: 1055-1064. doi:10.1002/hipo.20573


Author Shi, Feng
Liu, Bing
Zhou, Yuan
Yu, Chunshui
Jiang, Tianzi
Title Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies
Journal name Hippocampus   Check publisher's open access policy
ISSN 1050-9631
1098-1063
Publication date 2009-11-01
Sub-type Article (original research)
DOI 10.1002/hipo.20573
Open Access Status Not yet assessed
Volume 19
Issue 11
Start page 1055
End page 1064
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72–1.11] and right (ES, 0.78; 95% CI, 0.57–0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37–1.84, in left; ES, 1.52, 95% CI, 1.31–1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 176 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 181 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 22 Oct 2011, 00:55:50 EST by Sylvie Pichelin on behalf of Queensland Brain Institute