Gene mapping in the wild with SNPs: Guidelines and future directions

Slate, Jon, Gratten, Jake, Beraldi, Dario, Stapley, Jessica, Hale, Matt and Pemberton, Josephine M. (2009) Gene mapping in the wild with SNPs: Guidelines and future directions. Genetica, 136 1: 97-107. doi:10.1007/s10709-008-9317-z


Author Slate, Jon
Gratten, Jake
Beraldi, Dario
Stapley, Jessica
Hale, Matt
Pemberton, Josephine M.
Title Gene mapping in the wild with SNPs: Guidelines and future directions
Journal name Genetica   Check publisher's open access policy
ISSN 0016-6707
1573-6857
Publication date 2009-05-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s10709-008-9317-z
Open Access Status DOI
Volume 136
Issue 1
Start page 97
End page 107
Total pages 11
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Abstract One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.
Formatted abstract
One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online: 9 September 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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Created: Sat, 22 Oct 2011, 00:50:02 EST by Jake Gratten on behalf of Queensland Brain Institute