Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses

Hernandez-Sanchez, J., Chatzipli, A., Beraldi, D., Gratten, J., Pilkington, J. G. and Pemberton, J. M. (2010) Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses. Genetics Research, 92 4: 273-281. doi:10.1017/S0016672310000340


Author Hernandez-Sanchez, J.
Chatzipli, A.
Beraldi, D.
Gratten, J.
Pilkington, J. G.
Pemberton, J. M.
Title Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses
Journal name Genetics Research   Check publisher's open access policy
ISSN 0016-6723
1469-5073
Publication date 2010-08-01
Year available 2010
Sub-type Article (original research)
DOI 10.1017/S0016672310000340
Open Access Status Not yet assessed
Volume 92
Issue 4
Start page 273
End page 281
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract Historical information can be used, in addition to pedigree, traits and genotypes, to map quantitative trait locus (QTL) in general populations via maximum likelihood estimation of variance components. This analysis is known as linkage disequilibrium (LD) and linkage mapping, because it exploits both linkage in families and LD at the population level. The search for QTL in the wild population of Soay sheep on St. Kilda is a proof of principle. We analysed the data from a previous study and confirmed some of the QTLs reported. The most striking result was the confirmation of a QTL affecting birth weight that had been reported using association tests but not when using linkage-based analyses.
Keyword Birth weight
body weight
Gene linkage disequilibrium
Gene mapping
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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Created: Sat, 22 Oct 2011, 00:45:46 EST by Jake Gratten on behalf of Queensland Brain Institute