Thick visual cortex in the early blind

Jiang, Jiefeng, Zhu, Wanlin, Shi, Feng, Liu, Yong, Li, Jun, Qin, Wen, Li, Kuncheng, Yu, Chunshui and Jiang, Tianzi (2009) Thick visual cortex in the early blind. The Journal of Neuroscience, 29 7: 2205-2211. doi:10.1523/JNEUROSCI.5451-08.2009

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Author Jiang, Jiefeng
Zhu, Wanlin
Shi, Feng
Liu, Yong
Li, Jun
Qin, Wen
Li, Kuncheng
Yu, Chunshui
Jiang, Tianzi
Title Thick visual cortex in the early blind
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2009-02-01
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.5451-08.2009
Open Access Status File (Publisher version)
Volume 29
Issue 7
Start page 2205
End page 2211
Total pages 7
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Formatted abstract
We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing the thickness of the visual cortex in humans with early- and late-onset blindness. The bilateral visual cortices of the early blind were significantly thicker than those of the late blind and the sighted controls, but the latter two groups did not differ significantly. This suggests reduced “pruning” of synapses in the visual cortex, which may be due to a lack of visual experience during a critical developmental period. These findings support the hypothesis that sensory experience is necessary for an appropriate regression and remodeling of neuronal processes and that synaptic regression might be a major determinant of macroscopic anatomical features like cortical thickness.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 85 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 21 Oct 2011, 20:52:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute