Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog

Keates, H. and Whittem, T. (2012) Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog. Research in Veterinary Science, 93 2: 904-906. doi:10.1016/j.rvsc.2011.10.003

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Author Keates, H.
Whittem, T.
Title Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
1532-2661
Publication date 2012-10-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.rvsc.2011.10.003
Open Access Status Not yet assessed
Volume 93
Issue 2
Start page 904
End page 906
Total pages 3
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Spontaneous ventilation after induction of anaesthesia with intravenous alfaxalone or propofol was evaluated in a dose escalation study using 6 dogs. Each dog was dosed at 1×, 2×, 5×, 10× and 20× multiples of the labelled doses (2mg/kg for alfaxalone; 6.5mg/kg for propofol), until apnoea was observed. For each administration, the entire calculated dose was delivered over 1 min. All 6 dogs ventilated spontaneously after labelled (1×) doses of each drug but became apnoeic at 5× dose of propofol versus 20× dose of alfaxalone. For propofol at 2× and 5× doses, 4 and 0 dogs ventilated spontaneously respectively. For alfaxalone at 2×, 5× and 10× doses all 6, 4 and 1 dog ventilated spontaneously, respectively. The median dose which induced apnoea was higher for alfaxalone (5×) than for propofol (2×) (p=0.05). We concluded that induction of anaesthesia with propofol is more likely to induce apnoea than with alfaxalone.
Formatted abstract
Spontaneous ventilation after induction of anaesthesia with intravenous alfaxalone or propofol was evaluated in a dose escalation study using 6 dogs. Each dog was dosed at 1×, 2×, 5×, 10× and 20× multiples of the labelled doses (2 mg/kg for alfaxalone; 6.5 mg/kg for propofol), until apnoea was observed. For each administration, the entire calculated dose was delivered over 1 min. All 6 dogs ventilated spontaneously after labelled (1×) doses of each drug but became apnoeic at 5× dose of propofol versus 20× dose of alfaxalone. For propofol at 2× and 5× doses, 4 and 0 dogs ventilated spontaneously respectively. For alfaxalone at 2×, 5× and 10× doses all 6, 4 and 1 dog ventilated spontaneously, respectively. The median dose which induced apnoea was higher for alfaxalone (5×) than for propofol (2×) (p = 0.05). We concluded that induction of anaesthesia with propofol is more likely to induce apnoea than with alfaxalone.
Keyword Alfaxalone
Apnoea
Dogs
Propofol
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 1 November 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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Created: Fri, 21 Oct 2011, 19:35:06 EST by Helen Keates on behalf of School of Veterinary Science