Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons

Atkinson, Susan E. and Williams, Stephen R. (2009) Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons. Journal of Neurophysiology, 102 2: 735-751. doi:10.1152/jn.00083.2009

Author Atkinson, Susan E.
Williams, Stephen R.
Title Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
Publication date 2009-08-01
Sub-type Article (original research)
DOI 10.1152/jn.00083.2009
Volume 102
Issue 2
Start page 735
End page 751
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The dendritic tree of layer 5 (L5) pyramidal neurons spans the neocortical layers, allowing the integration of intra- and extracortical synaptic inputs. Here we investigate the postnatal development of the integrative properties of rat L5 pyramidal neurons using simultaneous whole cell recording from the soma and distal apical dendrite. In young (P9-10) neurons, apical dendritic excitatory synaptic input powerfully drove action potential output by efficiently summating at the axonal site of action potential generation. In contrast, in mature (P25-29) neurons, apical dendritic excitatory input provided little direct depolarization at the site of action potential generation but was integrated locally in the apical dendritic tree leading to the generation of dendritic spikes. Consequently, over the first postnatal month the fraction of action potentials driven by apical dendritic spikes increased dramatically. This developmental remodeling of the integrative operations of L5 pyramidal neurons was controlled by a >10-fold increase in the density of apical dendritic Hyperpolarization-activated cyclic nucleotide (HCN)-gated channels found in cell-attached patches or by immunostaining for the HCN channel isoform HCN1. Thus an age-dependent increase in apical dendritic HCN channel density ensures that L5 pyramidal neurons develop from compact temporal integrators to compartmentalized integrators of basal and apical dendritic synaptic input.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 21 Oct 2011, 03:21:33 EST by Stephen Williams on behalf of Queensland Brain Institute