Functional disintegration in paranoid schizophrenia using resting-state fMRI

Zhou, Yuan, Liang, Meng, Tian, Lixia, Wang, Kun, Hao, Yihui, Liu, Haihong, Liu, Zhening and Jiang, Tianzi (2007) Functional disintegration in paranoid schizophrenia using resting-state fMRI. Schizophrenia Research, 97 1-3: 194-205. doi:10.1016/j.schres.2007.05.029


Author Zhou, Yuan
Liang, Meng
Tian, Lixia
Wang, Kun
Hao, Yihui
Liu, Haihong
Liu, Zhening
Jiang, Tianzi
Title Functional disintegration in paranoid schizophrenia using resting-state fMRI
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2007-12-01
Sub-type Article (original research)
DOI 10.1016/j.schres.2007.05.029
Open Access Status Not Open Access
Volume 97
Issue 1-3
Start page 194
End page 205
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract Schizophrenia is associated with mentalizing deficits that impact on social functioning and quality of life. Recently, schizophrenia has been conceptualized as a disorder of neural dysconnectivity and network level analyses offers a means of understanding the underlying deficits leading to mentalizing difficulty. Using an established mentalizing task (The Triangles Task), functional magnetic resonance images (fMRI) were acquired from 19 patients with schizophrenia and 17 age- and sex-matched healthy controls (HCs). Participants were required to watch short animations of two triangles interacting with each other with the interactions either random (no interaction), physical (patterned movement), or mental (intentional movement). Task-based Partial Least Squares (PLS) was used to analyze activation differences and commonalities between the three conditions and the two groups. Seed-based PLS was used to assess functional connectivity with peaks identified in the task-based PLS. Behavioural PLS was then performed using the accuracy from the mental conditions. Patients with schizophrenia performed worse on the mentalizing condition compared to HCs. Task-based PLS revealed one significant latent variable (LV) that explained 42.9% of the variance in the task, with theLV separating the mental condition from the physical and random conditions in patients with schizophrenia, but only the mental from physical in healthy controls. The mental animations were associated with increased modulation of the inferior frontal gyri bilaterally, left superior temporal gyrus, right postcentral gyrus, and left caudate nucleus. The physical/random animations were associated with increased modulation of the right medial frontal gyrus and left superior frontal gyrus. Seed-based PLS identified increased functional connectivity with the left inferior frontal gyrus (liFG) and caudate nucleus in patients with schizophrenia, during the mental and physical interactions, with functional connectivity with the liFG associated with increased performance on the mental animations. The results suggest that mentalizing deficits in schizophrenia may arise due to inefficient social brain networks.
Formatted abstract
Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including both “task-negative” (i.e., “default mode”) and “task-positive” networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia (N = 18) and healthy volunteers (N = 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyrus of the “task-negative” network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the “task-positive” network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients.
Keyword Schizophrenia
fMRI
Resting-state
Functional connectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 225 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 244 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 20 Oct 2011, 22:50:58 EST by Debra McMurtrie on behalf of Queensland Brain Institute