Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI

Zhou, Yuan, Liang, Meng, Jiang, Tianzi, Tian, Lixia, Liu, Yong, Liu, Zhening, Liu, Haihong and Kuang, Fan (2007) Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neuroscience Letters, 417 3: 297-302. doi:10.1016/j.neulet.2007.02.081


Author Zhou, Yuan
Liang, Meng
Jiang, Tianzi
Tian, Lixia
Liu, Yong
Liu, Zhening
Liu, Haihong
Kuang, Fan
Title Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2007-05-07
Sub-type Article (original research)
DOI 10.1016/j.neulet.2007.02.081
Open Access Status Not yet assessed
Volume 417
Issue 3
Start page 297
End page 302
Total pages 6
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Abstract The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal-directed tasks; however, the occurrence of the abnormality during rest in patients with schizophrenia has rarely been reported. In the present study, we selected bilateral Brodmann's area 46 as region of interest and analyzed the differences in the DLPFC functional connectivity pattern between 17 patients with first-episode schizophrenia (FES) and 17 matched controls using resting-state fMRI. We found that the bilateral DLPFC showed reduced functional connectivities to the parietal lobe, posterior cingulate cortex, thalamus and striatum in FES patients. We also found enhanced functional connectivity between the left DLPFC and the left mid-posterior temporal lobe and the paralimbic regions in FES patients. Our results suggest that functional dysconnectivity associated with the DLPFC exists in schizophrenia during rest. This may be partially related to disturbance in the intrinsic brain activity.
Keyword Schizophrenia
fMRI
Dorsolateral prefrontal cortex
Connectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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Created: Thu, 20 Oct 2011, 21:24:16 EST by Debra McMurtrie on behalf of Queensland Brain Institute