Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury

Agaisse, Herve´, Petersen, Ulla-Maja, Boutros, Michael, Mathey-Prevot, Bernard and Perrimon, Norbert (2003) Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Developmental Cell, 5 3: 441-450. doi:10.1016/S1534-5807(03)00244-2


Author Agaisse, Herve´
Petersen, Ulla-Maja
Boutros, Michael
Mathey-Prevot, Bernard
Perrimon, Norbert
Title Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
1878-1551
Publication date 2003-09-05
Sub-type Article (original research)
DOI 10.1016/S1534-5807(03)00244-2
Open Access Status Not yet assessed
Volume 5
Issue 3
Start page 441
End page 450
Total pages 10
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 20 Oct 2011, 20:19:40 EST by Ulla-maja Bailey on behalf of School of Chemistry & Molecular Biosciences